Polymorphic acetylation of nitrazepam.

Polymorphic acetylation of nitrazepam.

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).

The polymorphic acetylation of sulphapyridine in man.

Polymorphic acetylation of sulphamethazine in a Zimbabwe population.

Sulphamethazine, 8 mg/kg body weight, was administered orally in tablet form to 100 healthy volunteers and total and free sulphamethazine were determined in the six hour urine sample. The bimodal population frequency distribution for percentage acetylated sulphamethazine showed 42 of the tested population to be fast and 58 to be slow acetylators, that is, an estimation of q = 0.72 +/- 0.3 as th...

Nitrazepam in premedication.

The sedative effects of nitrazepam in a dose of 5 mg and 10 mg have been compared with Mandrax, a combination of methaqualone 250 mg with diphenhydramine 25 mg. Studies were carried out in gynaecological patients undergoing minor surgical operations using the scoring system previously described. The degree of sedation obtained after administration of the two dose levels of nitrazepam was compar...

Nitrazepam in Emotional Disorders of Childhood

The therapeutic results obtained with Nitrazepam in 30 children with emotional disorders between 4 and 14 years of age are reported, 17 children with habit disorders, 6 with behaviour, 5 with personality and 2 with Neurosis. Employing a flexible dosage schedule, a dose of 1/4 tablet to 1 tablet of 5 mg. Nitrazepam once to thrice daily was effective and safe. 24 of the 30 children (80%) showed r...